Yee Sun Tan, PhD

Research Fellow, Internal Medicine - Division of Rheumatology

Biography

After receiving my bachelor's and master's degree in Microbiology from National University of Singapore, I worked as a research technician studying hypoxia in cancer at the Johns Hopkins University before joining University of Maryland, School of Medicine for my graduate studies. My PhD degree in Biochemistry with Dr. Curt Civin focused on dissecting the roles of microRNAs in leukemia and hematopoietic stem cells. 

Research Interests

My long-term research interests lie in understanding key molecular and cellular pathways that drive inflammation in diseases such as cancer and autoimmune diseases. Our lab focuses on systemic lupus erythematosus (SLE), a complex autoimmune disease where patients exhibit increased interferon signatures in their skin, with an increased production and a robust, skewed interferon response that is regulated by PITX1. By studying how these interferon responses in the skin of SLE patients are regulated, we hope to develop improved and novel therapies for SLE.

Techniques

Flow cytometry, Molecular biology, Cell culture, Mouse models