Ling Qi, PhD

Professor of Molecular and Integrative Physiology
Professor of Internal Medicine, Division of Metabolism, Endocrinology & Diabetes
Accepting Students

Biography

Dr. Qi is Professor at the Department of Molecular & Integrative Physiology and the Department of Internal Medicine at the University of Michigan Medical School. The Qi laboratory is leading the effort to delineate the physiological role of endoplasmic reticulum-associated protein degradation (ERAD) and inflammation. Work from his laboratory has demonstrated the importance of ERAD in health and disease, and implicated ERAD as a potential target in many human diseases. In addition to research, he is a dedicated teacher and mentor. In May of 2014, he was awarded the SUNY Chancellor’s Award for Excellence in Teaching, a top award for the best teacher in New York State. He is the Chair of NIH Cellular Aspects of Diabetes and Obesity (CADO) study section and the President of Chinese American Diabetes Association (CADA).

Research Interests

Interdisciplinary discovery research focusing on cell biology, immunology and metabolism

Research Opportunities for Rotating Students

Rotation students will be working on the role of ER protein degradation in immunity; the role of inflammation in pancreatic beta cell regulation

Publications

1. Ji, Y.*, Sun, S.*, Shrestha, N., Darragh, L., Shirakawa, J., Xing, Y., He, Y., Carboneau, B.A., Kim, H., Oberhozler, J., Soleimanpour, S.A., Gannon, M., Liu, C., Naji, A., Kulkarni, R., Wang, Y., Kersten, S., and Qi, L. 2019. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 2019 Jun;20(6):677-686. PubMed PMID: 31110312; PubMed Central PMCID: PMC6531334. (Cover story)

2. Bhattacharya, A., Sun, S., Wang, H., Long, Q., Yin, L., Liu, M., Kersten, S., Zhang, K., and Qi, L. Hepatic ER-associated degradation manages FGF21 expression via CREBH during fasting-feeding and growth. EMBO J. 2018 (37):e99277 PMCID: PMC6236331. PMID: 30389665. NEWS and VIEWS in EMBO J. EDITOR’S CHOICE in Science Signaling. Recommended by F1000Prime.

3. Kim, G.H., Shi, G., Somlo, D., Haataja, L., Song, S., Long, Q., Arvan, P., Nillni, E.A., Low, M., Myers, G.M. Jr., and Qi, L. Hypothalamic endoplasmic reticulum-associated degradation regulates POMC maturation, feeding and age-associated obesity. J Clin Invest. 2018. Mar 1;128(3):1125-1140. PMCID: PMC5824855. PMID: 29457782 RESEARCH HIGHLIGHT in Nature Reviews Endocrinology.

4. Shi G*, Somlo D*, Kim GH*, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L. ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest. 2017 Oct 2;127(10):3897-3912. PMID: 28920920; PMCID: PMC5617659. J Clin Invest Commentary; RESEARCH HIGHLIGHT in Nature Reviews Nephrology.

5. Sun S*, Shi G*, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015 Dec;17(12):1546-55. PubMed PMID: 26551274; PubMed Central PMCID: PMC4670240.

6. Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, Péterfy M, Long Q, Qi L. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014 Sep 2;20(3):458-70. PubMed PMID: 25066055; PubMed Central PMCID: PMC4156539.