Genetics and epigenetics of complex autoimmune and inflammatory diseases; T cell DNA methylome in health and disease; functional genomics and systems biology in lupus and systemic vasculitis; Epigenomic variability and disease mechanisms
Currently we are focused on studying the regulation enzymes that add or remove histone modifications (known as chromatin modifying enzymes) and linking this regulation to phenotype during an immune response. Our labs have experience in a number of diseases models and a working knowledge of the inflammatory signals that are present in these models. We have begun to combine this knowledge with both classic immunological approaches and analysis of large data sets, including RNA-seq and ChIP-seq experiments, to dissect how specific chromatin modifying enzymes may contribute to immune cell...
Neuroimmunology; autoimmune diseases of the nervous system; cytokine and chemokine networks/ leukocyte interactions in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis
Pediatric Endocrinology, obesity, diet induced inflammation and its impact on clinical disease, high fat diet included myelopoiesis, and sexually dimorphic inflammatory responses to high fat diet
Lung inflammation, innate immunity, toll-like receptors
Lymphocyte recirculation and migration; Immunotherapy of malignant disease; T-cell trafficking during normal and pathologic immune responses; regulation of adhesion receptors involved in T-cell trafficking