Chemokine, cytokine and eicosanoid regulation of pulmonary fibrosis; pulmonary infections post bone-marrow transplant
1. Role of TET2 and/or DNMT3A in CD4+ T cell differentiation
2. Epigenetic regulation of memory vs. effector CD8+ T cell differentiation
3. Cooperation of co-occurring PTCL mutations with TET2 loss in T cell transformation
Development of immunotherapies for primary and metastatic brain cancer: from basic immunobiology mechanisms to translational immune-therapeutics. Tumor immune-microenvironment: its role in tumor progression and response to therapeutics. Cross talk between cancer cells and hematopoietic stem/progenitor cells. Epigenetic mechanisms affecting the migration of immune cells from peripheral lymphoid organs to the tumor microenvironment
Fundamental molecular mechanisms and cell biology of T lymphocyte activation. Advanced molecular imaging using light and electron microscopy. Focus on innate-like T cells, directed cellular immunotherapies, and HIV/T cell interactions
Lung immunity in humans and mice.
Specifically: immunopathogenesis of COPD; Efferocytosis; Interactions of lung leukocytes with the lung microbiome.
Role of Toll-like receptors on CD8+ and CD4+ T cells and NK cells in regards to chronic obstructive pulmonary disease; Immunopathogenesis of chronic obstructive pulmonary disease.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
Signal transduction, small molecules and immunomodulatory peptides in autoimmunity; Gene-environment interaction in autoimmunity;Molecular mechanisms of MHC-disease association
The interplay between innate immunity and autoimmune disease development. Specifically, I am interested in the cross-talk between dermal and systemic inflammation and how this may influence disease development.
Innate Immunity, Tumor Immunology, Oral Head & Neck Cancer, Autophagy, NLR proteins, Proteomics and CRISPR/Cas9 systems
Development of cancer immunotherapy using immune cells, such as T cells,
B cells and dendritic cells (DCs). Use of in vivo primed and in vitro activated effector T and B cells for cancer treatment, and generate DC-based cancer stem cell vaccines to target cancer stem cells
The current focus of my research is to discover the molecular pathways underlying the growth patterns of malignant brain tumors using state-of-the-art RNA sequencing and Chip sequencing techniques. My lab also studies the mechanisms which mediate the interactions between cancer cells and the tumor immune microenvironment, in both experimental models in humans and patients suffering from malignant brain tumors.
Obesity and Inflammation. Adipose tissue macrophages and lymphocyte activation with obesity. Dietary influences on inflammatory cell activation. Intravital microscopy on adipose tissue leukocytes
Notch signaling, hematopoietic stem cells, T cell differentiation and homeostasis, bone marrow transplantation, alloimmunity, autoimmunity
Regulation of the innate immune response against bacterial pneumonia, Role of the eicosanoids and their receptors in pneumococcal pneumonia, Impact of second hand tobacco smoke in lung disease, Role of adiponectin and leptin in inflammation and infection in obesity
Neuroimmunology; the Interplay between immune system and neural stem/progenitor cells in multiple sclerosis (MS); cytokine, neurotrophin production and neuroprotective mechanisms for neuroregeneration in MS. The mission is to enhance translational research by bridging basic research in neuroimmunology with human studies in MS
Innate host responses during bacterial infection, microbial pathogenesis, T cells and bacterial infection
Interface of the adaptive and innate immunity during host-pathogen interactions
Investigating the recruitment and function of myeloid cells (monocytes, dendritic cells, and macrophages) that accumulate in the lung in response to infection and/or injury
Bone marrow transplantation, GVHD/GVL