- Posttranscriptional gene regulation in lung inflammation and cancer - RNA biology - Asthma and allergy - The role of the RNA binding protein HuR in 1) allergen induced airway inflammation, and 2) helper T cell differentiation and function
T cell immunobiology, Epigenetics
Regulation of innate-like CD4 T cell development and function
Inflammation and cancer; role of gut microbiota and Nod-like receptors in colitis and cancer
Our laboratory is interested in finding new ways to optimize CD8+ T cell-based approaches to cancer immunotherapy. Projects under active investigation include an exploration of the immunostimulatory effects of a novel form of tumor ablation called histotripsy, and the investigation of the impact of effector and memory CD8+ T cells on cancer stem cells.
Lung immunity in humans and mice.
Specifically: immunopathogenesis of COPD; Efferocytosis; Interactions of lung leukocytes with the lung microbiome.
Pulmonary host defense against influenza and bacterial infections of the lung Role of microbiome on regulation of immune responses Neutrophil phenotypes during infection
Human T lymphocyte biology, rheumatoid arthritis, T cell interactions with synovial cells, regulation of TH17 cells
Role of Toll-like receptors on CD8+ and CD4+ T cells and NK cells in regards to chronic obstructive pulmonary disease; Immunopathogenesis of chronic obstructive pulmonary disease.
I have had a long-standing defined clinical and translational interest in the mechanisms underlying impaired diabetic wound healing. My long-term goal is to uncover the basic mechanisms responsible for the coordination of immune cells in early tissue repair processes, determine impairments in Type 2 Diabetes and translate this knowledge to the bedside.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
regulation of T-dependent B cell response, control of auto-reactive B cells
innate immunity, epithelia, food allergy, Inflammatory Bowel Diseases, eosinophilic esophagitis
Signal transduction, small molecules and immunomodulatory peptides in autoimmunity; Gene-environment interaction in autoimmunity;Molecular mechanisms of MHC-disease association
The microbiome & respiratory diseases; the mucosal immunobiology and microbiology of food allergies; and the microbiology, immunology and microbial ecology of the yeast Candida albicans.
Mucosal Immunology in gastrointestinal tract: host-microbial interaction in the pathogenesis of inflammatory bowel disease.
Cancer cell and host immune cell interactions in tumor microenvironment; Tumor tolerance mechanisms; TGF-b and TLR signaling
1. Cell trafficking and function in the hematolymphoid system. We study trafficking mechanisms of lymphocytes for development and effector functions. Special emphasis is on the roles of chemokine receptors and integrins in regulating the trafficking of various T cell populations (Th17, Th9, Th1, Tfh, Tfr, IL-10+ T cells, and FoxP3+ Tregs) and innate lymphoid cells (ILCs).
2. Mucosal immunity, inflammation, and cancer. Balanced immunity is important for prevention of inflammation and cancer. We study the interactive relationships among immunity, inflammation and cancer development in...
Intracellular signaling pathways controlling T lymphocyte activation, differentiation and death. Lymphatic vessel biology, cancer and angiogenesis
Tumor immunoediting, Inflamation, Human immunology
Epigenetics, chemokine and cytokine biology
Immunology/Mechanisms of Immunosuppression
Cancer Immunotherapy, Cancer Immune Escape, Immune Engineering
Development of cancer immunotherapy using immune cells, such as T cells,
B cells and dendritic cells (DCs). Use of in vivo primed and in vitro activated effector T and B cells for cancer treatment, and generate DC-based cancer stem cell vaccines to target cancer stem cells
Pulmonary immune responses to allergens and viral infections. Role of cytokines and chemokines
Computational imaging in cancer biology and therapy
Obesity and Inflammation. Adipose tissue macrophages and lymphocyte activation with obesity. Dietary influences on inflammatory cell activation. Intravital microscopy on adipose tissue leukocytes
Tumor Metabolism, Cancer, Pancreatic Cancer, Immunometabolism, Metabolomics, Autoimmunity
Impact of adipokines and metabolic disease on innate immunity and host defense against bacterial pneumonia
Neuroimmunology; the Interplay between immune system and neural stem/progenitor cells in multiple sclerosis (MS); cytokine, neurotrophin production and neuroprotective mechanisms for neuroregeneration in MS. The mission is to enhance translational research by bridging basic research in neuroimmunology with human studies in MS
The Markovitz laboratory focuses on understanding how human cellular factors control the replication of viruses, and retroviruses in particular. These studies are performed both to understand the biology of viruses and to develop possible therapies for these important human pathogens, as well as to exploit the viruses as a mechanism for understanding human cellular biology.
Vaccine delivery and Cancer immunotherapy
mucosal immunology, pathogenesis of lung fibrosis, herpesviral and bacterial infections post-stem cell transplant, bacterial superinfection post-influenza, diabetic wound healing
Nod-like receptors; Host defense against bacterial pathogens; Mucosal Immunity; Role of the microbiota in immunity and pathogen eradication; Inflammatory disease; inflammation and cancer
Innate immunity to intracellular bacterial pathogens
Over the last 15 years, my studies have primarily focused on host-pathogen interactions between the invasive fungus C. neoformans and the mammalian immune system.Specifically, we look into the mechanisms involved in the pathogenesis of Cryptococcus neoformans infection and the persistence of this microbe. Our studies also seek to understand both the effects of immunomodulation on host antifungal defenses and mechanisms of immune evasion exhibited by fungi, as well as to explore pre-clinical approaches of immuno-modulatory therapies.
Host defense against fungal lung infection; Biology of lung myeloid cells including monocytes, dendritic cells, and macrophages; Contribution of lung myeloid cells to lung fibrogenesis in response to airway and alveolar epithelial cell injury; Pathogenesis of deployment-related lung disease.
Mucosal Inflammation and Epithelial Pathobiology
Gastrointestinal PathologyHepatobiliary Pathology
Cell and molecular regulation of macrophage biology in inflammation, innate immunity, and fibrosis of the lung
Inflammatory/immune responses and tissue injury and repair
Transplantation immunology, accommodation, immunologic properties and genomic stability of stem cells, genetic basis of cell transformation and oncogenesis
Endoplasmic reticulum-associated protein degradation (ERAD) and inflammation