Chemokine, cytokine and eicosanoid regulation of pulmonary fibrosis; pulmonary infections post bone-marrow transplant
1. Role of TET2 and/or DNMT3A in CD4+ T cell differentiation
2. Epigenetic regulation of memory vs. effector CD8+ T cell differentiation
3. Cooperation of co-occurring PTCL mutations with TET2 loss in T cell transformation
B cell memory, B cell and immunoglobulin dependent T cell development and function and generation of diversity in health and disease
Development of immunotherapies for primary and metastatic brain cancer: from basic immunobiology mechanisms to translational immune-therapeutics. Tumor immune-microenvironment: its role in tumor progression and response to therapeutics. Cross talk between cancer cells and hematopoietic stem/progenitor cells. Epigenetic mechanisms affecting the migration of immune cells from peripheral lymphoid organs to the tumor microenvironment
Regulation of innate-like CD4 T cell development and function
Inflammation and cancer; role of gut microbiota and Nod-like receptors in colitis and cancer
Cellular and molecular mechanisms of leukocyte mobilization during granulomatous formation; pathology
Fundamental molecular mechanisms and cell biology of T lymphocyte activation. Advanced molecular imaging using light and electron microscopy. Focus on innate-like T cells, directed cellular immunotherapies, and HIV/T cell interactions
Viral pathogenesis; antiviral immunity
Lung immunity in humans and mice.
Specifically: immunopathogenesis of COPD; Efferocytosis; Interactions of lung leukocytes with the lung microbiome.
Human T lymphocyte biology, rheumatoid arthritis, T cell interactions with synovial cells, regulation of TH17 cells
Role of Toll-like receptors on CD8+ and CD4+ T cells and NK cells in regards to chronic obstructive pulmonary disease; Immunopathogenesis of chronic obstructive pulmonary disease.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
Regulation and control of humoral (antibody) immune response; intravital imaging and quantitative analysis of lymphocyte dynamic behavior in living
mice.
Signal transduction, small molecules and immunomodulatory peptides in autoimmunity; Gene-environment interaction in autoimmunity;Molecular mechanisms of MHC-disease association
Neuroimmunology; immunopathogenesis of viral infections of the central nervous system; innate immunity to viruses; immune mechanisms of neuronal and glial cell injury
The interplay between innate immunity and autoimmune disease development. Specifically, I am interested in the cross-talk between dermal and systemic inflammation and how this may influence disease development.
Mucosal Immunology in gastrointestinal tract: host-microbial interaction in the pathogenesis of inflammatory bowel disease.
Cancer cell and host immune cell interactions in tumor microenvironment; Tumor tolerance mechanisms; TGF-b and TLR signaling
Intracellular signaling pathways controlling T lymphocyte activation, differentiation and death. Lymphatic vessel biology, cancer and angiogenesis
Tumor immunoediting, Inflamation, Human immunology
Epigenetics, chemokine and cytokine biology
Immunology/Mechanisms of Immunosuppression
Innate Immunity, Tumor Immunology, Oral Head & Neck Cancer, Autophagy, NLR proteins, Proteomics and CRISPR/Cas9 systems
Development of cancer immunotherapy using immune cells, such as T cells,
B cells and dendritic cells (DCs). Use of in vivo primed and in vitro activated effector T and B cells for cancer treatment, and generate DC-based cancer stem cell vaccines to target cancer stem cells
The current focus of my research is to discover the molecular pathways underlying the growth patterns of malignant brain tumors using state-of-the-art RNA sequencing and Chip sequencing techniques. My lab also studies the mechanisms which mediate the interactions between cancer cells and the tumor immune microenvironment, in both experimental models in humans and patients suffering from malignant brain tumors.
Pulmonary immune responses to allergens and viral infections. Role of cytokines and chemokines
Chemokines and chemokine receptor signaling in cancer; molecular imaging
Obesity and Inflammation. Adipose tissue macrophages and lymphocyte activation with obesity. Dietary influences on inflammatory cell activation. Intravital microscopy on adipose tissue leukocytes
Regulation of the immune system in autoimmunity, asthma, cancer and infections by B lymphocytes
Notch signaling, hematopoietic stem cells, T cell differentiation and homeostasis, bone marrow transplantation, alloimmunity, autoimmunity
Regulation of the innate immune response against bacterial pneumonia, Role of the eicosanoids and their receptors in pneumococcal pneumonia, Impact of second hand tobacco smoke in lung disease, Role of adiponectin and leptin in inflammation and infection in obesity
Neuroimmunology; the Interplay between immune system and neural stem/progenitor cells in multiple sclerosis (MS); cytokine, neurotrophin production and neuroprotective mechanisms for neuroregeneration in MS. The mission is to enhance translational research by bridging basic research in neuroimmunology with human studies in MS
The role of DEK in cancer and autoimmunity; the role of vimentin in the immune response; endogenous retroviruses; development of antiviral agents
Vaccine delivery and Cancer immunotherapy
Innate host responses during bacterial infection, microbial pathogenesis, T cells and bacterial infection
Nod-like receptors; Host defense against bacterial pathogens; Mucosal Immunity; Role of the microbiota in immunity and pathogen eradication; Inflammatory disease; inflammation and cancer
Innate immunity to intracellular bacterial pathogens
Interface of the adaptive and innate immunity during host-pathogen interactions
Investigating the recruitment and function of myeloid cells (monocytes, dendritic cells, and macrophages) that accumulate in the lung in response to infection and/or injury
Mucosal Inflammation and Epithelial Pathobiology
Gastrointestinal PathologyHepatobiliary Pathology
Cell and molecular regulation of macrophage biology in inflammation, innate immunity, and fibrosis of the lung
Inflammatory/immune responses and tissue injury and repair
Transplantation immunology, accommodation, immunologic properties and genomic stability of stem cells, genetic basis of cell transformation and oncogenesis
Antigen presentation and HLA polymorphisms in infection
Bone marrow transplantation, GVHD/GVL