Chemokine, cytokine and eicosanoid regulation of pulmonary fibrosis; pulmonary infections post bone-marrow transplant
- Posttranscriptional gene regulation in lung inflammation and cancer - RNA biology - Asthma and allergy - The role of the RNA binding protein HuR in 1) allergen induced airway inflammation, and 2) helper T cell differentiation and function
Our laboratory is interested in finding new ways to optimize CD8+ T cell-based approaches to cancer immunotherapy. Projects under active investigation include an exploration of the immunostimulatory effects of a novel form of tumor ablation called histotripsy, and the investigation of the impact of effector and memory CD8+ T cells on cancer stem cells.
Lung immunity in humans and mice.
Specifically: immunopathogenesis of COPD; Efferocytosis; Interactions of lung leukocytes with the lung microbiome.
Role of Toll-like receptors on CD8+ and CD4+ T cells and NK cells in regards to chronic obstructive pulmonary disease; Immunopathogenesis of chronic obstructive pulmonary disease.
Dr. Gallagher's lab investigates the role of bone marrow stem cells in diabetic wound healing and peripheral artery disease (PAD).
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
Signal transduction, small molecules and immunomodulatory peptides in autoimmunity; Gene-environment interaction in autoimmunity;Molecular mechanisms of MHC-disease association
Pulmonary immunology; fungal pathogenesis and microflora-mediated modulation of immunity
Mucosal immunology, inflammation, and cancer
Migration of innate immune cells and lymphocytes
Development of T cells (FoxP3+, Tr1, andTh17 cells) and dendritic cells in health and disease Roles of vitamin A and retinoic acid in regulation of the immune system
Roles of microbial metabolites (short chain fatty acids) in regulation of the immune system
Roles of hormones in regulation of the immune system
Regulation of Tfh, GC-T cells, and B cell antibody production
Gut Microbiota and Immune Responses
Cancer Immunotherapy, Cancer Immune Escape, Immune Engineering
Development of cancer immunotherapy using immune cells, such as T cells,
B cells and dendritic cells (DCs). Use of in vivo primed and in vitro activated effector T and B cells for cancer treatment, and generate DC-based cancer stem cell vaccines to target cancer stem cells
Obesity and Inflammation. Adipose tissue macrophages and lymphocyte activation with obesity. Dietary influences on inflammatory cell activation. Intravital microscopy on adipose tissue leukocytes
Regulation of the innate immune response against bacterial pneumonia, Role of the eicosanoids and their receptors in pneumococcal pneumonia, Impact of second hand tobacco smoke in lung disease, Role of adiponectin and leptin in inflammation and infection in obesity
Neuroimmunology; the Interplay between immune system and neural stem/progenitor cells in multiple sclerosis (MS); cytokine, neurotrophin production and neuroprotective mechanisms for neuroregeneration in MS. The mission is to enhance translational research by bridging basic research in neuroimmunology with human studies in MS
The Markovitz laboratory focuses on understanding how human cellular factors control the replication of viruses, and retroviruses in particular. These studies are performed both to understand the biology of viruses and to develop possible therapies for these important human pathogens, as well as to exploit the viruses as a mechanism for understanding human cellular biology.
Nod-like receptors; Host defense against bacterial pathogens; Mucosal Immunity; Role of the microbiota in immunity and pathogen eradication; Inflammatory disease; inflammation and cancer
Interface of the adaptive and innate immunity during host-pathogen interactions
Investigating the recruitment and function of myeloid cells (monocytes, dendritic cells, and macrophages) that accumulate in the lung in response to infection and/or injury