Steven K. Lundy, Ph.D.
Steven K. Lundy, Ph.D. is a Research Associate Professor in the Department of Internal Medicine-Rheumatology at the University of Michigan Medical School. Steve earned his Bachelor of Science degree in Biochemistry from Oakland University, Auburn Hills, Michigan in 1987. He then worked in the Immunology Department at the Mayo Foundation in Rochester, MN for six years as a Research Technician, followed by three years as a Lab Manager in Radiation Oncology at Wayne State University in Detroit, Michigan.
Steve then pursued his doctorate in the laboratory of Dov L. Boros in the Department of Immunology and Microbiology at Wayne State University, graduating in 2001. His thesis was entitled "Mechanisms of CD4+ T cell apoptosis during murine Schistosoma mansoni infection". The major findings of his dissertation were that B cells, particularly CD5+ B-1a cells, in schistosome infected mice expressed Fas ligand and were able to kill activated T cells.
Dr. Lundy did his first post-doctoral fellowship in Nick Lukacs' lab in Pathology at the University of Michigan studying the role of T cells and B cells in the cockroach allergen-induced asthma model, and again found evidence that CD5+ B cells regulated T cell death and the severity of disease. His second post-doctoral fellowship was in the lab of David Fox in Internal Medicine-Rheumatology at the University of Michigan, and is where he made the transition to faculty in 2006.
Steve has an active research lab within the Division of Rheumatology and has been a research mentor to several graduate and undergraduate students. Dr. Lundy currently holds grants from the Dryer Foundation, and the National Institutes of Health. Past sponsorship was also received from the Arthritis Foundation, the Michigan Diabetes Research and Training Center, and the National Institutes of Health.
Dr. Lundy is an active participant in the Graduate Immunology Program of the Program in Biomedical Sciences. He has been a course coordinator and instructor for IMM850 Experimental Immunology. He also gives lectures in other courses in the Immunology Program as well as teaching first and second-year medical students in the University of Michigan Medical School. Steve has also given basic immunology presentations to clinical fellows and faculty within the Division of Rheumatology and other units.
Our laboratory studies immune regulation of T lymphocytes at the level of interactions with antigen presenting cells. Over stimulation and/or deficient suppression of T cells is a major problem in autoimmune diseases and allergy. In contrast, poor stimulation or over-suppression of T cells can lead to decreased immune responses to infectious agents and/or inadequate tumor surveillance. The broad goal is to better understand the interactions between T cells and APC that cause disease, and to design methods to manipulate these interactions as treatment strategies. The current emphasis is on understanding the biology and effector functions of Fas ligand-positive, ‘killer’ B lymphocytes in animal models of autoimmune arthritis. Other projects include: 1) characterizing Fas ligand expression in human B cells; 2) identifying killer B cell subsets in mice; 3) developing new models of arthritis in mice; 4) studying T cell interactions with patient-derived synovial fibroblasts that act as antigen presenting cells; and 5) using natural exosomes and plastic beads to modulate T cell reactions in vitroand in vivo. Our lab has active collaborations with many Immunology Program faculty, as well as collaborations with the Dental School, School of Public Health, the Biomedical Engineering Department, and the Kellogg Eye Center.
We currently have funding from an NIH-NIAID R03 grant and are part of the UM Autoimmune Center of Excellence, which will also be funded by the NIH-NIAID.