Sonya Wolf

Immunology Program Graduate Student Candidate

Biography

I Received my bachelors degree from Prairie View A&M University. Attended a post-baccalaureate program at University of North Carolina Chapel Hill.
 

Research Interests

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects up to .5% of the US population and nearly 90% of patients are women. These SLE patients experience devastating organ damage mediated by autoantibody production, immune complex deposition, and elevated production of type I interferons (IFNs). SLE disease activity occurs in a series of flares that incrementally damage kidneys, skin, liver and other organs. Currently there has been growing evidence for the role of the skin in regulating lupus flare development. Type I IFNs are purported to be important cytokines in the development of SLE, but their role in cutaneous induced systemic flare development has not been well understood. UVB response and TLR 7 cutaneous stimulation have been associated with lupus development in patients and in mice, but the role of type I IFNs in this process still remains unclear. My project addresses two main questions: 1) What role do type I IFNs play in TLR7 –mediated lupus development.2) What role do type I IFNs play in the UVB response in lupus prone mice.
 

 

Awards

2014 – present Rackham Merit Fellowship
2016 Rackham Conference Travel Award
2017 Monte V. Hobbs Award 2017 Student Ally Diversity Grant- Immunology
2017 Rackham Student Research Grant 2017 Arthritis National Research Foundation (ANRF) Travel Awards
2017 John Wallace Diversity Award 2018 Student Ally diversity Grant- Immunology
2018 The Abraham H Grant Scholastic Award 2018 Immunology honorable mention for promoting DEI

Abstracts

Wolf SJ, Reed TJ, Kahlenberg JM. (May, 2015). Challenging dogma: Lupus nephritis flares are independent of type I interferon signaling. Poster presented at: DEPARTMENT OF INTERNAL MEDICINE 24th ANNUAL RESEARCH SYMPOSIUM Ann Arbor, MI

Wolf SJ, Reed TJ, Kahlenberg JM. (June, 2015). Challenging dogma: Lupus nephritis flares are independent of type I interferon signaling. Poster presented at: Immunology Annual Retreat. Oregon, OH

Wolf SJ, Reed TJ, Kahlenberg JM. (November, 2016). TLR-7-Mediated Lupus Nephritis Flares Are Independent of Type I Interferon Signaling. Talk presented at: American College of Rheumatology annual Conference Washington, DC

Wolf SJ, Theros J, Reed TJ, Kahlenberg JM (November, 2017). TLR-7-Mediated Lupus Nephritis Flares Are Independent of Type I Interferon Signaling. Talk presented at: Autumn Immunology Conference Chicago, IL

Wolf SJ, Theros J, Kahlenberg JM (May, 2018). UVB induces early increases in IgG+ B cells in lupus-prone but not wild-type mice. Poster presented at: American Association of Immunologist Conference Austin, TX

Wolf SJ, Theros J, Kahlenberg JM (May, 2018). UVB induces early increases in B cells in lupus-prone mice in a type I interferon dependent manner. Poster presented at: Internal Medicine Research Symposium Ann Arbor, MI

Publications

Moore QC, Smith C, Wolf S, Solomon O, Williams B, Thompson AK. Examining the immune response of pneumolysin exposed human corneal epithelial cells in a keratitis model. BIOS 2014; 85(4):199-206. doi: http://www.bioone.org/doi/10.1893/0005-3155-85.4.199.

Wang C, Wolf S, Khan M, Mao-Draayer Y (2015) Interleukin-6 Receptor: A Novel Therapeutic Target for Neuromyelitis Optica. Brain Disord Ther. doi: 10.4172/2168-975X.1000e119

Clark KL, Reed TJ, Wolf SJ, Lowe L, Hodgin JB, Kahlenberg JM. Epidermal injury promotes nephritis flare in lupus-prone mice. J Autoimmun 2015; 65:38-48. PMCID: PMC4679658

Hirsch ML, Wolf SJ, Samulski RJ. “Delivering transgenic DNA exceeding the carrying capacity of AAV vectors.” In Gene Therapy for Neurological Disorders: Methods and Protocols, 1st ed., Fredric P. Manfredsson, editor. New York: Springer (Humana Press Inc.), 2016, pp. 21-39.

Sonya J. Wolf, Jonathan Theros, Tammi J. Reed , Jianhua Liu, Irina L. Grigorova, Giovanny J. Martínez-Colón, Chaim O. Jacob M.D, Jeffrey B. Hodgin ,J. Michelle Kahlenberg. TLR-7-mediated Lupus Nephritis Is Independent of Type I Interferon Signaling. Journal of Immunology 2018;201(2):393-405.PMID: 29884703

Sonya J. Wolf, Shannon N. Estadt, Johann E. Gudjonsson, J. Michelle Kahlenberg. Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity. Frontiers in Immunology “submitted”