I received my B.S. in Molecular, Cellular, and Developmental Biology from Yale University in the spring 2011. I joined the University of Michigan Medical School's Medical Scientist Training Program in the fall of 2011 and achieved candidacy in the Immunology Program's PhD program in the spring of 2014.
My research explores the molecular mechanisms governing antigen crosspresentation, a process key which is key to activating the adaptive immune response to tumors and certain viruses, and which contributes to immune tolerance.
Herman & Dorothy Miller Award for Innovative Immunology Research
Ikaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation. Toubai T, Guoqing H, Rossi C, Mathewson N, Oravecz-Wilson K, Cummings E, Wu J, Sun Y, Choi S, Reddy P.
Mature T cell responses are controlled by microRNA-142. Sun Y, Oravecz-Wilson K, Mathewson N, Wang Y, McEachin R, Liu C, Toubai T, Wu J, Rossi C, Braun T, Saunders T, Reddy P. J Clin Invest. 2015 Jul 1;125(7):2825-40. doi: 10.1172/JCI78753. Epub 2015 Jun 22.
BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice. Sun Y, Wang Y, Toubai T, Oravecz-Wilson K, Liu C, Mathewson N, Wu J, Rossi C, Cummings E, Wu D, Wang S, Reddy P. Blood. 2015 Apr 23;125(17):2724-8. doi: 10.1182/blood-2014-08-598037. Epub 2015 Mar 16.
Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice. Toubai T, Hou G, Mathewson N, Liu C, Wang Y, Oravecz-Wilson K, Cummings E, Rossi C, Evers R, Sun Y, Wu J, Choi SW, Fang D, Zheng P, Liu Y, Reddy P. Blood. 2014 May 29;123(22):3512-23. doi: 10.1182/blood-2013-12-545335. Epub 2014 Apr 2.