Raymond Yung, M.B., Ch.B.

Professor and Chief, Division of Geriatric and Palliative Medicine, Department of Internal Medicine
Director, Institute of Gerontology
Co-Director, Geriatrics Center

Biography

Dr. Raymond Yung is a professor of Internal Medicine and a research scientist at the Veterans Affairs Ann Arbor Geriatric Research, Education and Clinical Center. He obtained his medical school training from the University of Liverpool in England (1986). After completing an internal medicine residency at Sinai Hospital in Detroit, he received further clinical and research fellowship training in Rheumatology (1994) and Geriatric Medicine (1996) at the University of Michigan, where he has since remained a faculty member. Dr. Yung is a recipient of the NIH Individual National Research Service Award (1994-1996) and Clinical Investigator Award (1997-2002), and the American Federation for Aging Research Paul Beeson Physician Faculty Scholars in Aging Research Award (1998-2001). In addition, he has received the American College of Rheumatology Senior Rheumatology Scholar Award (1994). He is currently funded by the NIH in his research effort on the effects of aging on T cell chemokine function. In addition to his research endeavor, Dr. Yung is also the Director of the Musculoskeletal Sequence in the Medical School curriculum. Dr. Yung was named chief, Division of Geriatric and Palliative Medicine and co-director, Geriatrics Center in 2011.

Research Interests

My research focus is in immunosenescence and the effects of inflammation in aging. There are 3 ongoing research projects:

1. The effects of early life micronutrients on chronic inflammatory disease development. This NIH/NIA-sponsored program examines how prenatal micronutrient alters the susceptibility to chronic inflammatory and autoimmune disease development in the F1 generation through the epigenetic system. The first part of this work has just been accepted for publication in the Journal of Nutrition, with Colin as the lead/first author. We are currently examining the mechanisms and effect of the pre-natal diet on cardiovascular disease, lupus and rheumatoid arthritis development.

2. Age-related obesity and ‘inflamm-aging’. Our earlier work has defined key T cell chemokine changes in murine and human aging, as a mechanism explaining the observation that normal aging is associated with low grade chronic inflammation. In our most recent publication (Nov 2011, J Immunol), in collaboration with Carey Lumeng from the Department of Pediatrics, we showed that age-related adipose tissue macrophages may be a source of inflammation in aging. We also reported similarities and differences between diet- and age-related adipose tissue T cells and macrophages.

3. Dendritic cell function in aging. In the project, we have been examining the effects of aging on the efficacy of dendritic cell cancer immunotherapy. We showed that dendritic cells from aged mice are less competent as a therapeutic agent in melanoma immunotherapy. Furthermore, we are exploring the underlying molecular mechanisms for age-associated changes in the innate immune system.

Publications

Lumeng CN, Liu J, Geletka L, Delaney C, DelProposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. Journal of Immunology 187:12:6208-6216, 2011. PMCID: PMC3237772.

Delaney C, Hoeltzel M, Warner R, Johnson K, Yung R. Maternal micronutrient supplementation suppresses T cell chemokine receptor expression and function in F1 progeny. Journal of Nutrition 142:1329-1335, 2012. PMCID: 3374669.

Delaney C, Garg SK, Fernandes C, Allen RH, Stabler S, Hoeltzel M, and Yung R. Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE-/- mice. PLoS ONE. 8(2): e56253. doi:10.1371/journal.pone.0056253, 2013. PMC3578836

Garg SK, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R. Aging is associated with increased regulatory T cell function. Aging Cell 13(3):441-448, 2014. PMCID: PMC4032602.

Ghosh AM, Garg SK, Mau T, O’Brien M, Liu J, Yung R. Elevated endoplasmic reticulum (ER)-stress response contributes to adipose tissue inflammation in aging. J Gerontol Biol Sci. 2014. 1–10 doi:10.1093/gerona/ glu186 PMID: 25324219

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