Peter Mancuso, Ph.D.
My Bachelors and and Masters degrees were in Food Science and Nutrition. After a brief career in the food industry, the focus of my PhD dissertation was the impact of dietary fatty acids on eicosanoid metabolism and acute lung injury. I continued to focus on eicosanoids during my postdoctoral fellowship where I studied their role in bactericidal mechanisms in macrophages. I have expanded my research to include the study of adipokines in inflammation and host defense against Klebsiella and pneumococcal pneumonia using animal models of malnutrition, obesity, and cigarette smoke exposure. I am currently an Associate Professor in the Dept of Nutritional Sciences where I also teach courses on environment and the immune response and the pathophysiology of obesity.
A major focus in my lab is the innate immune response against pneumococcal and Klebsiella pneumonia. We are currently interested in the impact of obesity on mechanisms of host defense in alveolar macrophages. Another area of research is on the role of PGE2 and its receptor EP2 in second-hand cigarette smoke induced macrophage proliferation and emphysemia. My laboratory also participates in epidemiologic studies that explore the association between adipokines in osteoarthritis, cardiovascular disease, depression, asthma, sleep apnea, and chronic obstructive pulmonary disease in human populations.