Mikel Haggadone

Immunology Program Graduate Student Candidate

Biography

Mike is a native Midwesterner and proud graduate of the University of Michigan, receiving his B.S. in Cellular and Molecular Biology in 2014. In addition to his scientific pursuits, Mike thoroughly enjoys running ultramarathons, traveling, and living sustainably in beautiful Ann Arbor, Michigan. After performing a brief stint of research in California, Mike enthusiastically returned to the University of Michigan in January 2016 to pursue his graduate work in immunology.
 

Research Interests

Since joining the Peters-Golden lab, Mike has been working to understand how cigarette smoking affects the immunoregulatory properties of a subset of small, cell-derived structures called extracellular vesicles (EVs). In the lung, EVs secreted by the main tissue-resident immune cell, the alveolar macrophage, contain anti-inflammatory cargo that is acquired by surrounding epithelial cells, a mechanism critical for the maintenance of lung homeostasis. Thus, as impediments of EV cargo packaging, secretion, and transmission may serve to exacerbate pulmonary inflammation, defining these cellular and molecular pathways could help us to uncover novel therapeutic targets for treating smoking-related lung disease.
 

Awards

2016 Graduate Research Fellowship - National Science Foundation

2014 High Honors in Cellular and Molecular Biology - University of Michigan Program in Biology

2014 Bachelor of Science, with High Distinction - University of Michigan College of Literature, Science, and the Arts

2014 Sidney Fine Teaching Award - University of Michigan College of Literature, Science, and the Arts Honors Program

2014 Phi Beta Kappa Society - Alpha of Michigan Chapter

2013 Undergraduate Research Fellowship - American Heart Association

2013 Honor Society of Phi Kappa Phi - University of Michigan Chapter

2012 Research Internship in Science and Engineering - German Academic Exchange Service

2011 Outstanding Poster Award - University of Michigan Undergraduate Research Opportunity Program Symposium

 

Abstracts

Haggadone, MD and Peters-Golden, M. Extracellular vesicle degradation by novel house dust mite phospholipase activity. Am. J. Respir. Crit. Care Med. (2017) 195:A1360.

Grailer, J, Haggadone, M, and Ward, P. Catecholamines promote an M2 macrophage activation phenotype. J. Immunol. (2013) 190:63.7.

Publications

Immunology Mentor