Mikel Haggadone

Immunology Program Graduate Student Candidate

Biography

Mike is a native Midwesterner and proud graduate of the University of Michigan, receiving his B.S. in Cellular and Molecular Biology in 2014. In addition to his scientific pursuits, Mike thoroughly enjoys teaching and engaging in student mentorship, volunteering at local running events, participating in ultra-distance trail races, and enjoying Ann Arbor’s wonderful plant-based cuisine. After performing a brief stint of research in California, Mike enthusiastically returned to the University of Michigan in January 2016 to pursue his graduate work in immunology.
 

Research Interests

Since joining the Peters-Golden lab, Mike has been studying a subset of small, cell-derived structures called extracellular vesicles (EVs). In the lung, EVs secreted by the main tissue-resident immune cell, the alveolar macrophage (AM), contain anti-inflammatory cargoes that are acquired by surrounding epithelial cells. This mechanism is critical for the maintenance of lung homeostasis. While the functional importance of EVs has been defined in numerous contexts, the cellular and molecular determinants of EV cargo packaging remain poorly understood. As a result, Mike has begun to reveal novel mechanisms by which oxidative stress responses alter packaging of protein cargoes into AM-derived EVs. In addition to revealing how the immunoregulatory properties of EVs might be altered in the context of lung inflammation, Mike is also leveraging his findings to understand how EV protein cargo packaging occurs at the molecular level.
 

Awards

2018 Award for Excellence in Teaching - University of Michigan Office of Graduate and Postdoctoral Studies
2016 Graduate Research Fellowship - National Science Foundation 2014 High Honors in Cellular and Molecular Biology - University of Michigan Program in Biology
2014 Bachelor of Science, with High Distinction - University of Michigan College of Literature, Science, and the Arts
2014 Sidney Fine Teaching Award - University of Michigan College of Literature, Science, and the Arts Honors Program
2014 Phi Beta Kappa Society - Alpha of Michigan Chapter
2013 Undergraduate Research Fellowship - American Heart Association
2013 Honor Society of Phi Kappa Phi - University of Michigan Chapter
2012 Research Internship in Science and Engineering - German Academic Exchange Service
2011 Outstanding Poster Award - University of Michigan Undergraduate Research Opportunity Program Symposium

Abstracts

Haggadone, MD, Mancuso, P, Bazzill, J, Moon, JJ, and Peters-Golden, M. Reactive oxygen species enhance suppressor of cytokine signaling 3 packaging into alveolar macrophage-derived microvesicles. Am. J. Respir. Crit. Care Med. (2018) 197:A4488.

Haggadone, MD and Peters-Golden, M. Extracellular vesicle degradation by novel house dust mite phospholipase activity. Am. J. Respir. Crit. Care Med. (2017) 195:A1360.

Grailer, J, Haggadone, M, and Ward, P. Catecholamines promote an M2 macrophage activation phenotype. J. Immunol. (2013) 190:63.7.

Publications

Immunology Mentor