Matthew Schaller, PhD
Dr. Schaller received a B.S. in Nutrition from the University of Connecticut in 2001 and a Ph.D. from the University of Michigan Immunology Program in 2005. After receiving a fellowship from the Francis foundation, he remained at U of M to complete his post-doc. His lab works closely with the labs of Drs. Kunkel and Gallagher to study the cause and effect of epigenetic regulation of the immune system.
Project 1: The role of IFN-beta and the H3K9Me3 methyltransferase SetDB2 in health and disease. We have demonstrated that SetDB2 upregulation in macrophages is regulated by IFN-beta, and that that expression of this enzyme causes an immunosuppressive phenotype that may be beneficial in the wound healing response and detrimental during bacterial pneumonia that occurs after influenza infection. We are currently translating our findings from mouse models to human patients. Project 2: The epigenetic regulation of multifunctional T cell phenotype in tuberculosis. We have found a very specific phenotype related to the role of multifunctional T cells. This T cell phenotype, characterized by the secretion of 4 different cytokines, is correlated with protection from active tuberculosis infection.