Holly Turula

Immunology Program Graduate Student Candidate

Biography

I graduated from Portland State University with a degree in Biology. During and after my degree I worked as a technician at Oregon Health and Science University in the lab of Dr. Ann Hill investigating the common animal facility contaminant murine norovirus, as well as murine and human cytomegalovirus. I then helped to start up the lab of Dr. Christopher Snyder at Thomas Jefferson University where I investigated CD8 T cell dynamics in response to murine cytomegalovirus infection.
 

Research Interests

My long-term goal in the Wobus lab is to better understand how norovirus overcomes gastrointestinal host defenses to become the leading cause of food-borne illness in the US. Early events in viral entry dictate host range, initiation of immune responses, and overall pathogenesis, and so represent an ideal point for intervention. In order to reveal targets for the development of antiviral therapies, we examine early virus-host interactions utilizing the natural mouse pathogen murine norovirus (MNV). My immediate goal is to investigate mechanisms of norovirus interaction with the intestinal epithelial barrier, specifically the role of secretory IgA and commensal bacteria in the facilitation of norovirus infection.
 

 

Awards

2013 Rackham Merit Fellowship Award, Rackham Graduate School, UM
2015, 2016, 2018 Rackham Conference Travel Award, Rackham Graduate School, UM
2016 Young Investigator Travel Award, Society of Mucosal Immunology
2016 T32 Digestive Sciences Training Grant Recipient, UM 2017 Willie Hobbs Moore Achievement Award, UM
2017 Excellence in Teaching Award, Program in Biomedical Science, UM

Abstracts

Turula H, Pry A, Fava J, Wilke C, Wobus CE. Natural Secretory Immunoglobulins Facilitate Norovirus Infection. Poster. American Association of Immunology. Austin, TX. 2018.

Turula H, Pry A, Fava J, Wilke C, Wobus CE. Natural Secretory Immunoglobulins Facilitate Norovirus Infection. Poster. University of Michigan Center for Gastrointestinal Research Retreat. Ann Arbor, MI. 2018.

Turula H, Gonzalez-Hernandez MB, Wobus CE. Secretory Immunoglobulins Facilitate Norovirus Infection by Promoting Tolerance. Poster. International Congress of Mucosal Immunology. Washington D.C., USA. July 2017.

Turula H, Gonzalez-Hernandez MB, Pry A, Elftman MD, Wobus CE. Living as a Threesome in the Gut: Murine Norovirus, Bacteria and Secretory IgA. Poster. Mucosal Immunology Course and Symposium. Microbiota and Mucosal Immunity: Rules of Engagement in Health and Disease.Toronto, Canada. 2016.

Turula H, Gonzalez-Hernandez MB, Pry A, Elftman MD, Wobus CE. Living as a Threesome in the Gut: Murine Norovirus, Bacteria and Secretory IgA. Poster. University of Michigan Center for Gastrointestinal Research Retreat. Ann Arbor, MI. 2016.

Turula H, Gonzalez-Hernandez MB, Pry A, Elftman MD, Wobus CE. Natural Secretory IgA Facilitates Murine Norovirus Transcytosis. Oral and Poster. Autumn Immunology Conference. Chicago, IL. 2015

Kolawole A, Gonzalez-Hernandez M, Turula H, Yu C, Elftman MD, Wobus CE. Oral Norovirus Infection Is Blocked in Mice Lacking Peyer’s Patches and Mature M Cells. Poster. International Congress on Mucosal Immunology. Berlin, Germany. 2015

Turula H, Smith CJ, Grey F, Zurbach KA, Snyder CM. An OT-1 adoptive transfer model reveals wide host-to-host variability in the inflation of a single T cell clone and interclonal competition during MCMV infection. Poster. Keystone Symposium on Molecular and Cellular Biology: Viral Immunity. Keystone, CO. 2012.

Turula H, Snyder CM. Transgenic T cells stimulated by MCMV encoded antigen are rejected from congenic hosts after acute clonal expansion. Poster. American Society for Microbiology, Philadelphia Infection and Immunity Forum. Philadelphia, PA. 2011

Turula, H, et al., An OT-1 adoptive transfer model reveals wide host-to-host variability in the inflation of a single T cell clone and interclonal competition during MCMV infection. Poster. Keystone Symposium on Molecular and Cellular Biology: Viral Immunity. 2012. Turula, H, et al., Transgenic T cells stimulated by MCMV encoded antigen are rejected from congenic hosts after acute clonal expansion. Philadelphia Infection and Immunity Forum, American Society of Microbiology, 2011

Publications

Immunology Mentor