Holly Turula

Immunology Program Graduate Student Candidate

Biography

I graduated from Portland State University with a degree in Biology. During and after my degree I worked as a technician at Oregon Health and Science University investigating the role of murine norovirs infection on murine cytomegalovirus infection. I then helped to start up a laboratory at Thomas Jefferson University and investigated CD8 T cell dynamics in response to murine cytomegalovirus infection.

Research Interests

My long-term goal in the Wobus lab at the University of Michigan is to better understand how norovirus overcomes gastrointestinal host defenses to become the leading cause of food-borne illness in the US. My immediate goal is to investigate mechanisms of norovirus interaction with the intestinal epithelial barrier, specifically the role of secretory IgA and commensal bacteria in the facilitation of norovirus transcytosis through the intestinal epithelium. Early events in viral entry dictate host range, initiation of immune responses, and overall pathogenesis, and so represent an ideal point for intervention. In order to reveal targets for the development of antiviral therapies, we examine early virus-host interactions utilizing the natural mouse pathogen murine norovirus (MNV).

 

Awards

  • 2013 Rackham Merit Fellowship Award
  • 2015 Rackham Conference Travel Award
  • 2016 Young Investigator Travel Award, Society of Mucosal Immunology
  • 2016 T32 Digestive Sciences Training Grant Recipient

 

 

Abstracts

Published Abstracts
Turula H, Gonzalez-Hernandez MB, Pry A, Elftman MD, Wobus CE. Living as a Threesome in the Gut: Murine Norovirus, Bacteria and Secretory IgA. Poster. University of Michigan Center for Gastrointestinal Research Retreat. Ann Arbor, MI. 2016.

Turula H, Gonzalez-Hernandez MB, Pry A, Elftman MD, Wobus CE. Natural Secretory IgA Facilitates Murine Norovirus Transcytosis. Oral and Poster. Autumn Immunology Conference. Chicago, IL. 2015

Kolawole A, Gonzalez-Hernandez M, Turula H, Yu C, Elftman MD, Wobus CE. Oral Norovirus Infection Is Blocked in Mice Lacking Peyer’s Patches and Mature M Cells. Poster. International Congress on Mucosal Immunology. Berlin, Germany. 2015

Turula H, Smith CJ, Grey F, Zurbach KA, Snyder CM. An OT-1 adoptive transfer model reveals wide host-to-host variability in the inflation of a single T cell clone and interclonal competition during MCMV infection. Poster. Keystone Symposium on Molecular and Cellular Biology: Viral Immunity. Keystone, CO. 2012.

Turula H, Snyder CM. Transgenic T cells stimulated by MCMV encoded antigen are rejected from congenic hosts after acute clonal expansion. Poster. American Society for Microbiology, Philadelphia Infection and Immunity Forum. Philadelphia, PA. 2011

Turula, H, et al., An OT-1 adoptive transfer model reveals wide host-to-host variability in the inflation of a single T cell clone and interclonal competition during MCMV infection. Poster. Keystone Symposium on Molecular and Cellular Biology: Viral Immunity. 2012.

Turula, H, et al., Transgenic T cells stimulated by MCMV encoded antigen are rejected from congenic hosts after acute clonal expansion. Philadelphia Infection and Immunity Forum, ASM, 2011

Publications

Immunology Mentor