Gary Huffnagle, Ph.D.

Nina and Jerry D Luptak Professor
Research Professor, Mary H Weiser Food Allergy Center
Professor, Department of Internal Medicine, Pulmonary & Critical Care Medicine
Professor, Department of Molecular, Cellular and Developmental Biology
Professor, Department of Microbiology and Immunology
Accepting Students


Gary B. Huffnagle, PhD received his PhD in immunology from the University of Texas Southwestern Medical School. He is a Professor of Pulmonary and Critical Care Medicine and Professor of Microbiology and Immunology at the University of Michigan Medical School. He was elected as a member of the American Academy of Microbiology of the American Society for Microbiology in 2013 and is a frequent long-standing reviewer for the National Institutes of Health. His research interests for the past two decades include the interaction between opportunistic fungal pathogens, the fungal/bacterial microbiome, and the immune system during allergies and respiratory disease. He co-leads a multi-laboratory research group whose focus is on the immunology, pathobiology and microbiology of mucosal surfaces with interests and expertise encompassing the interdisciplinary approaches listed above, including applying high-throughput sequencing and gene expression technologies to biological processes and disease. He is the current chair of the inter-college, inter-departmental undergraduate microbiology program at the University of Michigan. He has written a book for a general audience, entitled The Probiotics Revolution, as well as participated in television, radio, magazine and newspaper interviews on the topic. In recognition of his efforts in both research and education, Dr. Huffnagle was awarded a Faculty Recognition Award from the President/Provost's Office at the University of Michigan in 2010.

Research Interests

Our laboratory's research interests are focused on the interaction between the microbiome and the immune system, both in control of pulmonary and intestinal inflammation and in control of infectious diseases (bacterial and fungal). Projects include the role of immune system-microbiome interactions in respiratory disease (COPD, allergy, IPF, lung inflammation) and food allergy. We utilize an interdisciplinary approach that combines research in pathophysiology, immunology, bacterial physiology and virulence, microbial ecology and microbial bioinformatics. Our translational research includes clinical sample analysis, in vitro experiments and in vivo models.

Research Opportunities for Rotating Students

In vivo and in vitro studies underlying mechanisms associated with food allergies