Cara Porsche

Immunology Program Graduate Student Candidate

Biography

Cara graduated with a B.S. in Biomedical Sciences from Colorado State University in 2012. After working as a technician at the University of Colorado’s Anschutz Medical Campus, she matriculated to the University of Michigan in 2015 for her graduate studies in immunology.

Research Interests

The immune response and nutrient metabolism are two important systems that regulate homeostasis. Although they seem to play disparate roles, studies have shown the two are tightly coupled. They come into immediate contact within adipose tissue and become dysregulated in obese conditions. Tissue both hypertrophies and contains increased populations of immune cells with increased adiposity. This leads to chronic low-grade inflammation, which seems to be the critical link between obesity and insulin resistance, type II diabetes, and fatty liver disease.

Cara’s research aims to understand the role of antigen presentation by adipose tissue macrophages and dendritic cells. This will provide information regarding potential differences in their induction of the adaptive immune response and inflammation.

Awards

• Ruth L Kirchstein National Research Service Award (F31) – 2018
• University of Michigan's Office of Graduate and Postdoctoral Studies Excellence in Service – Honorable Mention - 2018
• Trainee/Fellow: Training Program in Translational Cardiovascular Research and Entrepreneurship – 2017
• Graduate with Honors, Veterinary Medicine and Biomedical Sciences Department, Colorado State University - 2012

Abstracts

Oral Presentations

• CD4+ adipose tissue T cells assume a senescent pheontoye in obese mice and humans. UM Summer Diabetes Symposium, University of Michigan, Ann Arbor, MI. August 7, 2018.
• Deciphering the impact of niche and diabetes on adipose tissue T cell function. Frontiers in Cardiovascular Science Seminar, University of Michigan, Ann Arbor, MI. May 7, 2018.
• Extrathymic CD4+ CD8+ Double Positive T cells in Obesity and Diabetes. Autumn Immunology Conference, Chicago, IL. November 18, 2017.

Poster Presentations

• CD4+ adipose tissue T cells assume a senescent pheontoye in obese mice and humans. FASEB Science Research Conference, Snowmass, CO. August 14, 2018.
• Deciphering the impact of niche and diabetes on adipose tissue T cell function. University of Michigan Immunology Retreat, Graduate Hotel, Ann Arbor, MI. June 7, 2018.
• Extrathymic CD4+ CD8+ Double Positive T cells in Obesity and Diabetes. University of Michigan Immunology Retreat, Ann Arbor, MI. June 12, 2017.
• Extrathymic CD4+ CD8+ Double Positive T cells in Obesity and Diabetes. University of Michigan, Brehm Center for Diabetes Research: Summer Diabetes Symposium, Ann Arbor, MI. August 8, 2017.
• Body Condition Score Does Not Predict Myocardial Triglyceride Content in Canids. College of Veterinary Medicine and Biomedical Sciences Research Symposium, Fort Collins, CO. January 12, 2012.

Publications

Immunology Mentor