Bethany Moore, PhD

Galen B. Toews, MD Collegiate Professor of Pulmonary and Critical Care Medicine
Professor of Internal Medicine, Division of Pulmonary and Critical Care Medicine
Professor of Microbiology and Immunology
Director Graduate Program in Immunology
Accepting Students

Biography

Dr. Moore received her B.A. in Microbiology from the University of Texas at Austin in 1986 and her PhD in Immunology from the University of Texas Southwestern Medical School in Dallas in 1992. She performed post-doctoral studies at UT Southwestern from 1992-1994, and then at Stanford University from 1994-1997. She joined the faculty at the University of Michigan as a Research Investigator in 1997 and has risen through the ranks where she now holds the position of Professor with tenure. Dr. Moore has been recognized for her research accomplishments both nationally and locally. In 2014, she received the "Recognition Award for Scientific Accomplishments" from the American Thoracic Society and was inducted into the University of Michigan League of Research Excellence. In addition to her research activities, she teaches undergraduate Virology, directs the Graduate Program in Immunology and is active in education and mentoring via MICHR.

Research Interests

Dr. Moore’s research has focused on two main areas. The first is the pathogenesis of pulmonary fibrosis and the second is in infectious complications in the lung following stem cell transplantation. In her pulmonary fibrosis work, Dr. Moore has made contributions to our understanding of chemokine and eicosanoid regulation of the disease pathogenesis with a particular focus on alveolar-epithelial cell interactions and fibrocytes. She has also studied how herpesviral infections, aging and matricellular proteins impact fibrotic disease outcomes. Her work in these areas involves animal modeling as well as translational projects. Her work in the area of stem cell transplantation has focused on alterations in innate immune cell function which increase susceptibility to bacterial infections and on alterations to adaptive immunity which impair host defense against viral pathogens. She has demonstrated a major role for prostaglandin E2 as an inhibitor of alveolar macrophage and neutrophil function post-transplant and is currently working to understand how effector T cell responses are skewed from protective Th1 to pathogenic Th17 responses leading to pneumonitis and fibrosis following herpesviral infection in transplant recipients.

Research Opportunities for Rotating Students

Potential rotation projects involve the regulation of inflammasome activation post-stem cell transplant, and projects to understand how innate immune cell activity is differentially regulated in the lung vs. the periphery post-transplant.

Publications

http://orcid.org/0000-0003-3051-745X

The pubmed link which is less complete is also available here: http://www.ncbi.nlm.nih.gov/pubmed/?term=Moore+BB

Current Student Advisees