Benjamin Segal, M.D.

Holtom-Garrett Professor of Neurology
Director, U-M Multiple Sclerosis Center


As the Holtom-Garrett Professor of Neurology, Dr. Segal directs the University of Michigan Multiple Sclerosis Center and Program in Neuroimmunology. He also serve as Chair of the Scientific Advisory Board, VA Multiple Sclerosis Centers of Excellence-East and is co-Chair of the Americas Committee on Research and Teaching in MS (ACTRIMS) planning committee. The UM MS Center provides multidisciplinary care for over 3,300 patients with MS. The Center is engaged in numerous trials of novel drugs and procedures for the treatment of relapsing-remitting and progressive forms of MS. In addition, Dr. Segal oversees a basic laboratory program in which animal models are used to elucidate the roles of leukocyte subsets, and cytokine and chemokine pathways, in CNS pathology as well as regeneration.

Research Interests

Research efforts in the Segal laboratory span preclinical, translational, and clinical studies in neuroimmunological disease. The laboratory investigates the role of cytokine and chemokines, and the interplay between the acquired and innate immune systems, in animal models of neuroinflammation as well as in subjects with MS and related disorders. Strategies to exploit the "protective" aspects of the immune system to promote nerve fiber regeneration and remyelination are also under investigation.

Research Opportunities for Rotating Students

- Immune mediated axonal regeneration
- Role of myelin associated inhibitors in the immune response
- Myeloid cells and related factors in Multiple Sclerosis and its animal models


Current Student Advisees